Custom service: cyclic peptides
The formation of a disulphide bond is shown as a 2 Da loss in mono-isotopic mass in a high-end MS.We offer custom production of peptides containing lactam bridges or disulfide bonds. Even multiple bonds can be made, where each bond is directed to ensure correct conformation. Our Defensins are examples of such peptides. Making these peptides is in most cases straight forward. Nevertheless, when the objective is to obtain high quality material, we know from experience that you need the better reagents, a sound synthesis methodology, and quality control to match it.
State of the art quality control warrants excellent quality, as discussed in our article on the production of high quality peptides. As an example, a nanospray quadrupole MS will clearly show the 2 Da loss in molecular weight compared to the linear peptide and prove successful disulphide bond formation.
Additonal information
Order cyclic peptides
Innovagen was founded in 1992, at a time when custom peptide synthesis services were not as common as they are today. Since then we have provided the scientific community with thousands peptides many containing lactam or disulphide bridges. You will benefit from our long experience, commitment to providing excellent quality and customer service.
References
Examples of references of customers using our peptides containing one or more disulphide bonds provided by Innovagen include;
Claire Marchal, F. Schramm, A. Kern, B. J. Luft, X. Yang, T. Schuijt, J. Hovius, B. Jaulhac & N. Boulanger.
Antialarmin Effect of Tick Saliva during the Transmission of Lyme Disease.
Infection and Immunity, 2011, p. 774-785, Vol. 79, No. 2
Jonas Persson, Mats Ohlin
Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1
Journal of Immunological Methods Volume 316, Issues 1-2, 30 October 2006, Pages 116-124