Long peptides

At what point are we talking about proteins rather than peptides? Traditionally it has been said by some that a sequence of 50 amino acids or more is a protein, and shorter sequence are peptides. Today it is possible to synthesize very long chains of amino acids. The upper limit for peptide synthesis is sequence dependent but it is somewhere around 100-120 AA - although technological advances push the limit. At these lengths one may consider recombinant production of proteins as an alternative as it is more cost effective. But there are certain benefits to chemical synthesis that motivate the higher cost, such as material without tags, excellent purity, and the ability to add modifications or dyes at specific sites.

Additional information

Custom production

Innovagen has serviced the research community since 1992. In that time we have delivered synthetic peptides of various lengths. We have seen the importance of thinking quality in every step of the production, and we have learned that you need the combination of raw materials, synthesis methodology, equipment, and QC in order to obtain a high quality product. You will particularly benefit from our experience when it comes to making these longer peptides.

References

Examples of references of customers using our custom peptide synthesis services, where long peptides have been obtained, include;

J. Li, R. Kokkola, S. Tabibzadeh, R. Yang, M. Ochani, X. Qiang, H. E. Harris, C. J. Czura, H. Wang, L. Ulloa, H. Wang, H. S. Warren, L. L. Moldawer, M. P. Fink, U. Andersson, K. J. Tracey & H. Yang.

Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1.

Mol Med. 2003 Jan-Feb; 9(1-2): 37–45.

A. Orlova1, V. Tolmachev, R. Pehrson, M. Lindborg, T. Tran, M. Sandström, F. Y. Nilsson, A.Wennborg, L. Abrahmsén & J. Feldwisch.

Synthetic Affibody Molecules: A Novel Class of Affinity Ligands for Molecular Imaging of HER2-Expressing Malignant Tumors.

Cancer Res March 1, 2007 67; 2178

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