Monospecifc antibodies are antibodies that target the same antigen. They are either monoclonal antibodies or polyclonal antibodies that have been purified by affinity chromotography using the antigen as ligand.
This means that a polyclonal monospecific antibody raised against a synthetic peptide, can be a time-saving, cost effective and highly specific alternative to a monoclonal antibody. Some examples of projects where this strategy has been successfully used, include;
Since 1992, Innovagen has been providing the scientific community with research materials. Our experience, dedication to quality and excellent customer service will give you the best conditions for a successful outcome of your custom antibody project.
Examples of references of customers using our custom antibody services include;
Selective killing of candidate AML stem cells by antibody targeting of IL1RAP
M. Askmyr, H. Ågerstam, N.Hansen, S.Gordon, A.Arvanitakis, M.Rissler, G.Juliusson, J.Richter, M.Järås, T.Fioretos
Blood May 2013, 121 (18) 3709-3713; DOI: 10.1182/blood-2012-09-458935
Parhamifar L, Sime W, Yudina Y, Vilhardt F, Mörgelin M, et al. 2010
Ligand-Induced Tyrosine Phosphorylation of Cysteinyl Leukotriene Receptor 1 Triggers Internalization and Signaling in Intestinal Epithelial Cells.
PLoS ONE 5(12): e14439. doi:10.1371/journal.pone.0014439
Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, et al. 2010
Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii.
PLoS Biol 8(12): e1000576. doi:10.1371/journal.pbio.1000576
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